A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

ResourceAPlatformforGenerationofChamber-SpecificCardiacTissuesandDiseaseModelingGraphicalAbstractHighlightsdPositiveforcefrequencyandpost-restpotentiationareachievedinhumantissuesdEngineeredatrialandventriculartissueshavedistinctelectrophysiologyanddrugresponsesdAtrio-ventriculartissuesshowspatiallyconfineddrugresponsesdLong-termelectricalconditioningenablespolygeniccardiacdiseasemodelingAuthorsYimuZhao,NaimehRafatian,NicoleT.Feric,...,UlrichBroeckel,PeterH.Backx,MilicaRadisicCorrespondencep.backx@utoronto.ca(P.H.B.),m.radisic@utoronto.ca(M.R.)InBriefAscalablecardiactissuecultivationplatformenablesassessmentofmultipleparametersofatrialandventriculartissuefunction,drugtesting,anddiseasemodeling.Zhaoetal.,2019,Cell176,913–927February7,2019ª2018ElsevierInc.https://doi.org/10.1016/j.cell.2018.11.042ResourceAPlatformforGenerationofChamber-SpecificCardiacTissuesandDiseaseModelingYimuZhao,1NaimehRafatian,2NicoleT.Feric,3,4BrianJ.Cox,5,6RoozbehAschar-Sobbi,2,3ErikaYanWang,4PrafulAggarwal,7Boya